The IOI hosts a multidisciplinary research programme that is based on a wide range of capabilities that include AMR surveillance, the characterisation of mechanisms of drug resistance and modes of action of antibiotics, and drug discovery and development.
AMR burden and surveillance
- International studies with global surveillance and assessment programmes in LMICs
- Bacterial culturing
- Global AMR strain collection
- Molecular epidemiology
- Antibiotic susceptibility profiling
- Next-generation sequencing
Molecular mechanisms
- Characterization of mechanisms of drug action
- Elucidation of resistance mechanisms
- Next-generation sequencing
- Bacterial culturing
- Antibiotic susceptibility profiling
- Molecular microbiology
- Protein/target production
- Protein analysis
- Structural biology
Drug discovery
- High-throughput screening
- Biochemical and cell-based assays
- PK/PD and ADME evaluations
- Assay development
- Compound libraries
- Small molecule analysis
- Target validation
- Structural elucidation
Drug development
- Medicinal/synthetical chemistry
- Biosynthesis
- Compound optimization
- Drug metabolism & pharmacokinetics
- Structural biology
- In vivo testing
In-silico analyses
- Bioinformatics
- Computational chemistry
- Structural modelling
