Bacterial Antimicrobial Resistance: Surveillance and Prevention
IOI's Prof Timothy Walsh guest edits special edition of PLOS Medicine on AMR
IOI's Prof Timothy Walsh guest edits special edition of PLOS Medicine on AMR
Here we report the discovery of very potent inhibitors of the SARS-CoV-2 main protease (Mpro).
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Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic. Jangir, P.K., Yang, Q., Shaw, L.P., Caballero, J.D., Ogunlana, L., Wheatley, R., Walsh, T.R., MacLean, R.C. eLife. 2022;11:e78834. Available from: https://elifesciences.org/articles/78834
Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Carvalho, M.J., Sands, K., Thomson, K., Portal, E., Mathias, J., Milton, R., Gillespie, D., Dyer, C., Akpulu, C., Boostrom, I., Hogan, P., Saif, H., Ferreira, A., Nieto, M., Hender, T., Hood, K., Andrews, R., Watkins, W. J., Hassan, B., Chan, G., Bekele, D., Solomon, S., Metaferia, G., Basu, S., Naha, S., Sinha, A., Chakravorty, P., Mukherjee, S., Iregbu, K., Modibbo, F., Uwaezuoke, S., Audu, L., Edwin, C.P., Yusuf, A.H., Adeleye, A., Mukkadas, A.S., Zahra, R., Shirazi, H., Muhammad, A., Ullah, S.N., Jan, M.H., Akif, S., Mazarati, J.B., Rucogoza, A., Gaju, L., Mehtar, S., Bulabula, A.N.H., Whitelaw, A., Roberts, L., BARNARDS Group, Walsh, T.R. Nat Microbiol. 2022;7:1337–47. Available from: https://www.nature.com/articles/s41564-022-01184-y
Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries. Sands K, Carvalho MJ, Spiller OB, Portal EAR, Thomson K, Watkins WJ, Mathias J, Dyer C, Akpulu C, Andrews R, Ferreira A, Hender T, Milton R, Nieto M, Zahra R, Shirazi H, Muhammad A, Akif S, Jan MH, Iregbu K, Modibbo F, Uwaezuoke S, Chan GJ, Bekele D, Solomon S, Basu S, Nandy RK, Naha S, Mazarati J-, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, Walsh TR. BMC Infect Dis. 2022;22(1) Available from: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07541-w
Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Chowdhury R, Abboud MI, Wiley J, Tumber A, Markolovic S, Schofield CJ. Sci Rep. 2022;12(1) Available from: https://www.nature.com/articles/s41598-022-10028-y
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins. Belle R, Kamps JJAG, Poater J, Kumar K, Pieters BJGE, Salah E, Claridge TDW, Paton RS, Bickelhaupt FM, Kawamura A, Schofield CJ, Mecinović J. Commun Chem. 2022;5(1) Available from: https://www.nature.com/articles/s42004-022-00640-4
Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation. Brewitz L, Onisko BC, Schofield CJ. J Biol Chem. 2022;298(8) Available from: https://www.jbc.org/article/S0021-9258(22)00570-1/fulltext
Global burden of antimicrobial resistance: Essential pieces of a global puzzle. Walsh TR, Zahra R, Iregbu K, Peacock SJ, Stewardson A. Lancet. 2022;399(10344):2347-8. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00939-4/fulltext
Penicillin derivatives inhibit the SARS-CoV-2 main protease by reaction with its nucleophilic cysteine. Malla TR, Brewitz L, Muntean D-, Aslam H, Owen CD, Salah E, Tumber A, Lukacik P, Strain-Damerell C, Mikolajek H, Walsh MA, Schofield CJ. J Med Chem. 2022;65(11):7682-96. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02214
Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins. Leissing TM, Hardy AP, Chan H, Wang Y, Tumber A, Chowdhury R, Feng T, Coleman ML, Cockman ME, Kramer HB, Berridge G, Fischer R, Kessler BM, Ratcliffe PJ, Lu X, Schofield CJ. J Biol Chem. 2022;298(6) Available from: https://www.jbc.org/article/S0021-9258(22)00460-4/fulltext
Mass spectrometric assays reveal discrepancies in inhibition profiles for the SARS-CoV-2 papain-like protease. Brewitz L, Kamps JJAG, Lukacik P, Strain-Damerell C, Zhao Y, Tumber A, Malla TR, Orville AM, Walsh MA, Schofield CJ. ChemMedChem. 2022;17(9) Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202200016
Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem J, Schofield CJ. Proc Natl Acad Sci U S A. 2022;119(18) Available from: https://www.pnas.org/doi/10.1073/pnas.2117310119
To our friend, John. Walsh TR, Pittet D. Lancet Infect Dis. 2022;22(5):583-4. Available from: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00182-7/fulltext
Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: An international multisite prospective observational study. Milton R, Gillespie D, Dyer C, Taiyari K, Carvalho MJ, Thomson K, Sands K, Portal EAR, Hood K, Ferreira A, Hender T, Kirby N, Mathias J, Nieto M, Watkins WJ, Bekele D, Abayneh M, Solomon S, Basu S, Nandy RK, Saha B, Iregbu K, Modibbo FZ, Uwaezuoke S, Zahra R, Shirazi H, Najeeb SU, Mazarati J-, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw AC, Walsh TR, BARNARDS Group, Chan GJ. Lancet Global Health. 2022;10(5):e661-72. Available from: https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00043-2/fulltext
Silent circulation of BKC-1-producing Klebsiella pneumoniae ST442: Molecular and clinical characterization of an early and unreported outbreak. Martins WMBS, Lenzi MH, Narciso AC, Dantas PP, Andrey DO, Yang QE, Sands K, Medeiros EA, Walsh TR, Gales AC. Int J Antimicrob Agents. 2022;59(5) Available from: https://www.sciencedirect.com/science/article/abs/pii/S0924857922000681
Genomic insights into the mechanism of carbapenem resistance dissemination in Enterobacterales from a tertiary public heath setting in South Asia. Farzana R, Jones LS, Rahman MA, Sands K, van Tonder AJ, Portal E, Criollo JM, Parkhill J, Guest MF, John Watkins W, Pervin M, Boostrom I, Hassan B, Mathias J, Kalam MA, Walsh TR. Clin Infect Dis. 2022:ciac287. Available from: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac287/6567427
Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Kaur S, Tam NY, McDonough MA, Schofield CJ, Aik WS. Nucleic Acids Res. 2022;50(7):4148-60. Available from: https://academic.oup.com/nar/article/50/7/4148/6554164
Expanding the repertoire of low-molecular-weight pentafluorosulfanyl-substituted scaffolds. Jose A, Guest D, LeGay R, Tizzard GJ, Coles SJ, Derveni M, Wright E, Marrison L, Lee AA, Morris A, Robinson M, von Delft F, Fearon D, Koekemoer L, Matviuk T, Aimon A, Schofield CJ, Malla TR, London N, Greenland BW, Bagley MC, Spencer J, The Covid Moonshot Consortium. ChemMedChem. 2022;17(7) Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.202100641
Comparing long-read assemblers to explore the potential of a sustainable low-cost, low-infrastructure approach to sequence antimicrobial resistant bacteria with oxford nanopore sequencing. Boostrom I, Portal EAR, Spiller OB, Walsh TR, Sands K. Front Microbiol. 2022;13 Available from: https://www.frontiersin.org/articles/10.3389/fmicb.2022.796465/full
Distinct increase in antimicrobial resistance genes among Escherichia coli during 50 years of antimicrobial use in livestock production in China. Yang L, Shen Y, Jiang J, Wang X, Shao D, Lam MMC, Holt KE, Shao B, Wu C, Shen J, Walsh TR, Schwarz S, Wang Y, Shen Z. Nat Food. 2022;3(3):197-205. Available from: https://www.nature.com/articles/s43016-022-00470-6
Studies on the reactions of biapenem with VIM metallo β-lactamases and the serine β-lactamase KPC-2. Lucic A, Malla TR, Calvopiña K, Tooke CL, Brem J, McDonough MA, Spencer J, Schofield CJ. Antibiotics. 2022;11(3) Available from: https://www.mdpi.com/2079-6382/11/3/396
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: Implications for its role in viral genome stability and inhibitor identification. Baddock HT, Brolih S, Yosaatmadja Y, Ratnaweera M, Bielinski M, Swift LP, Cruz-Migoni A, Fan H, Keown JR, Walker AP, Morris GM, Grimes JM, Fodor E, Schofield CJ, Gileadi O, McHugh PJ. Nucleic Acids Res. 2022;50(3):1484-500. Available from: https://academic.oup.com/nar/article/50/3/1484/6509090
Structure-activity studies reveal scope for optimisation of ebselen-type inhibition of SARS-CoV-2 main protease. Thun-Hohenstein STD, Suits TF, Malla TR, Tumber A, Brewitz L, Choudhry H, Salah E, Schofield CJ. ChemMedChem. 2022;17(4) Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100582
Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Antimicrobial Resistance Collaborators. Lancet. 2022;399(10325):629-55. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis. Brereton CJ, Yao L, Davies ER, Zhou Y, Vukmirovic M, Bell JA, Wang S, Ridley RA, Dean LSN, Andriotis OG, Conforti F, Brewitz L, Mohammed S, Wallis T, Tavassoli A, Ewing RM, Alzetani A, Marshall BG, Fletcher SV, Thurner PJ, Fabre A, Kaminski N, Richeldi L, Bhaskar A, Schofield CJ, Loxham M, Davies DE, Wang Y, Jones MG. eLife. 2022;11 Available from: https://elifesciences.org/articles/69348
Synthesis and application of constrained amidoboronic acids using amphoteric boron-containing building blocks. Soor HS, Diaz DB, Tsui KY, Calvopiña K, Bielinski M, Tantillo DJ, Schofield CJ, Yudin AK. J Org Chem. 2022;87(1):94-102. Available from: https://pubs.acs.org/doi/10.1021/acs.joc.1c02015
Inhibition of JMJD6 by 2-oxoglutarate mimics. Islam MS, Thinnes CC, Holt-Martyn JP, Chowdhury R, McDonough MA, Schofield CJ. ChemMedChem. 2022;17(1) Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100398
Transmission of carbapenem resistance between human and animal NDM-positive Escherichia coli strains. Shen Y, Hu F, Wang Y, Yin D, Yang L, Chen Y, Xu C, Li J, Jiang J, Wang X, Fu Y, Shao D, Liu D, Ma T, Cai C, Shen Z, Wang S, Li J, Zhang R, Ke Y, Wu C, Shen J, Walsh TR, Wang Y. Engineering. 2022 Available from: https://www.sciencedirect.com/science/article/pii/S2095809922002089
Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease. Liu H, Xie Y, Wang X, Abboud MI, Ma C, Ge W, Schofield CJ. Alzheimer's Dementia. 2022 Available from: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12733
Early-onset neonatal sepsis in low-and middle-income countries: Current challenges and future opportunities. Sands K, Spiller OB, Thomson K, Portal EAR, Iregbu KC, Walsh TR. Infect Drug Resist. 2022;15:933-46. Available from: https://www.dovepress.com/early-onset-neonatal-sepsis-in-low--and-middle-income-countries-curren-peer-reviewed-fulltext-article-IDR
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors. Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt (Adrian) J, Calvopiña K, Turrientes M-, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Nat Chem. 2022;14(1):15-24. Available from: https://www.nature.com/articles/s41557-021-00831-x
Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations. Hvinden IC, Cadoux-Hudson T, Schofield CJ, McCullagh JSO. Cell Rep Med. 2021;2(12) Available from: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(21)00341-4
One-step synthesis of photoaffinity probes for live-cell MS-based proteomics. Fallon DJ, Lehmann S, Chung C-, Phillipou A, Eberl C, Fantom KGM, Zappacosta F, Patel VK, Bantscheff M, Schofield CJ, Tomkinson NCO, Bush JT. Chem Eur J. 2021;27(71):17880-8. Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202102036
First-in-class inhibitors of the ribosomal oxygenase MINA53. Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, Simelis K, Kawamura A, Johansson C, Passeri D, Pellicciari R, Ciogli A, Del Bufalo D, Ragno R, Coleman ML, Trisciuoglio D, Mai A, Oppermann U, Schofield CJ, Rotili D. J Med Chem. 2021;64(23):17031-50. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00605
Impact of carbapenem resistance on mortality in patients infected with Enterobacteriaceae: A systematic review and meta-analysis. Zhou R, Fang X, Zhang J, Zheng X, Shangguan S, Chen S, Shen Y, Liu Z, Li J, Zhang R, Shen J, Walsh TR, Wang Y. BMJ Open. 2021;11(12) Available from: https://bmjopen.bmj.com/content/11/12/e054971.long
Isocitrate dehydrogenase gene variants in cancer and their clinical significance. Cadoux-Hudson T, Schofield CJ, McCullagh JSO. Biochem Soc Trans. 2021;49(6):2561-72. Available from: https://portlandpress.com/biochemsoctrans/article/49/6/2561/230356/Isocitrate-dehydrogenase-gene-variants-in-cancer
2-oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nakashima Y, Brewitz L, Tumber A, Salah E, Schofield CJ. Nat Commun. 2021;12(1) Available from: https://www.nature.com/articles/s41467-021-26673-2
Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1. Liu S, Abboud MI, John T, Mikhailov V, Hvinden I, Walsby-Tickle J, Liu X, Pettinati I, Cadoux-Hudson T, McCullagh JSO, Schofield CJ. Commun Biolog. 2021;4(1) Available from: https://www.nature.com/articles/s42003-021-02743-5
Expansion of KPC-producing Enterobacterales in four large hospitals in Hanoi, Vietnam. Linh TD, Thu NH, Shibayama K, Suzuki M, Yoshida L, Thai PD, Anh DD, Duong TN, Trinh HS, Thom VP, Nga LTV, Phuong NTK, Thuyet BT, Walsh TR, Thanh LV, Bañuls A-, van Doorn HR, Van Anh T, Hoang TH. J Global Antimicrob Resist. 2021;27:200-11. Available from: https://www.sciencedirect.com/science/article/pii/S2213716521002137?via%3Dihub
Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: An international microbiology and drug evaluation prospective substudy (BARNARDS). Thomson KM, Dyer C, Liu F, Sands K, Portal E, Carvalho MJ, Barrell M, Boostrom I, Dunachie S, Farzana R, Ferreira A, Frayne F, Hassan B, Jones E, Jones L, Mathias J, Milton R, Rees J, Chan GJ, Bekele D, Mahlet A, Basu S, Nandy RK, Saha B, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Syed NU, Mazarati J-, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, van Hasselt JGC, Walsh TR, on behalf of the BARNARDS Group. Lancet Infect Dis. 2021;21(12):1677-88. Available from: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2821%2900050-5/fulltext
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Butryn A, Simon PS, Aller P, Hinchliffe P, Massad RN, Leen G, Tooke CL, Bogacz I, Kim I-, Bhowmick A, Brewster AS, Devenish NE, Brem J, Kamps JJAG, Lang PA, Rabe P, Axford D, Beale JH, Davy B, Ebrahim A, Orlans J, Storm SLS, Zhou T, Owada S, Tanaka R, Tono K, Evans G, Owen RL, Houle FA, Sauter NK, Schofield CJ, Spencer J, Yachandra VK, Yano J, Kern JF, Orville AM. Nat Commun. 2021;12(1) Available from: https://www.nature.com/articles/s41467-021-24757-7
Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Redhead MA, Owen CD, Brewitz L, Collette AH, Lukacik P, Strain-Damerell C, Robinson SW, Collins PM, Schäfer P, Swindells M, Radoux CJ, Hopkins IN, Fearon D, Douangamath A, von Delft F, Malla TR, Vangeel L, Vercruysse T, Thibaut J, Leyssen P, Nguyen T-, Hull M, Tumber A, Hallett DJ, Schofield CJ, Stuart DI, Hopkins AL, Walsh MA. Sci Rep. 2021;11(1) Available from: https://www.nature.com/articles/s41598-021-92416-4
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Davydova E, Shimazu T, Schuhmacher MK, Jakobsson ME, Willemen HLDM, Liu T, Moen A, Ho AYY, Małecki J, Schroer L, Pinto R, Suzuki T, Grønsberg IA, Sohtome Y, Akakabe M, Weirich S, Kikuchi M, Olsen JV, Dohmae N, Umehara T, Sodeoka M, Siino V, McDonough MA, Eijkelkamp N, Schofield CJ, Jeltsch A, Shinkai Y, Falnes PØ. Nat Commun. 2021;12(1) Available from: https://www.nature.com/articles/s41467-020-20670-7
Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. Powell LC, Abdulkarim M, Stokniene J, Yang QE, Walsh TR, Hill KE, Gumbleton M, Thomas DW. npj Biofilms and Microbiomes. 2021;7(1) Available from: https://www.nature.com/articles/s41522-020-00172-6
Structure-based design of selective fat mass and obesity associated protein (FTO) inhibitors. Shishodia S, Demetriades M, Zhang D, Tam NY, Maheswaran P, Clunie-O'Connor C, Tumber A, Leung IKH, Ng YM, Leissing TM, El-Sagheer AH, Salah E, Brown T, Aik WS, McDonough MA, Schofield CJ. J Med Chem. 2021;64(22):16609-25. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01204
Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding. Chan HTH, Moesser MA, Walters RK, Malla TR, Twidale RM, John T, Deeks HM, Johnston-Wood T, Mikhailov V, Sessions RB, Dawson W, Salah E, Lukacik P, Strain-Damerell C, Owen CD, Nakajima T, Świderek K, Lodola A, Moliner V, Glowacki DR, Spencer J, Walsh MA, Schofield CJ, Genovese L, Shoemark DK, Mulholland AJ, Duarte F, Morris GM. Chem Sci. 2021;12(41):13686-703. Available from: https://pubs.rsc.org/en/content/articlelanding/2021/sc/d1sc03628a
A new mutation in mgrb mediating polymyxin resistance in klebsiella variicola. Lenzi MH, Martins WM, Roch M, Ramos PL, Sands K, Cayô R, Walsh TR, Andrey DO, Gales AC. Int J Antimicrob Agents. 2021;58(5) Available from: https://pubmed.ncbi.nlm.nih.gov/34419577/
A role for arthropods as vectors of multidrug-resistant Enterobacterales in surgical site infections from South Asia. Hassan B, Ijaz M, Khan A, Sands K, Serfas G-, Clayfield L, El-Bouseary MM, Lai G, Portal E, Khan A, Watkins WJ, Parkhill J, Walsh TR. Nat Microbiol. 2021;6(10):1259-70. Available from: https://www.nature.com/articles/s41564-021-00965-1
Kinetic and structural characterization of the first B3 metallob-lactamase with an active-site glutamic acid. Wilson LA, Knaven EG, Morris MT, Pedroso MM, Schofield CJ, Brück TB, Boden M, Waite DW, Hugenholtz P, Guddat L, Schenk G. Antimicrob Agents Chemother. 2021;65(10) Available from: https://journals.asm.org/doi/10.1128/AAC.00936-21
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. Baddock HT, Newman JA, Yosaatmadja Y, Bielinski M, Schofield CJ, Gileadi O, McHugh PJ. Nucleic Acids Res. 2021;49(16):9294-309. Available from: https://academic.oup.com/nar/article/49/16/9294/6350770
Structural and mechanistic insights into the artemis endonuclease and strategies for its inhibition. Yosaatmadja Y, Baddock HT, Newman JA, Bielinski M, Gavard AE, Mukhopadhyay SMM, Dannerfjord AA, Schofield CJ, McHugh PJ, Gileadi O. Nucleic Acids Res. 2021;49(16):9310-26. Available from: https://academic.oup.com/nar/article/49/16/9310/6350767
Emergence of plasmid-mediated tigecycline resistance tet(X4) gene in Escherichia coli isolated from poultry, food and the environment in South Asia. Mohsin M, Hassan B, Martins WMBS, Li R, Abdullah S, Sands K, Walsh TR. Sci Total Environ. 2021;787 Available from: https://www.sciencedirect.com/science/article/abs/pii/S004896972102684X
Mobile colistin resistance enzyme MCR-3 facilitates bacterial evasion of host phagocytosis. Yin W, Ling Z, Dong Y, Qiao L, Shen Y, Liu Z, Wu Y, Li W, Zhang R, Walsh TR, Dai C, Li J, Yang H, Liu D, Wang Y, Gao GF, Shen J. Adv Sci. 2021;8(18) Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202101336
What is the catalytic mechanism of enzymatic histone N-methyl arginine demethylation and can it be influenced by an external electric field? Ramanan R, Waheed SO, Schofield CJ, Christov CZ. Chem Eur J. 2021;27(46):11750. Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202101174
What is the catalytic mechanism of enzymatic histone N-methyl arginine demethylation and can it be influenced by an external electric field? Ramanan R, Waheed SO, Schofield CJ, Christov CZ. Chem Eur J. 2021;27(46):11827-36. Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202101174
High-throughput crystallography reveals boron-containing inhibitors of a penicillin-binding protein with di- and tricovalent binding modes. Newman H, Krajnc A, Bellini D, Eyermann CJ, Boyle GA, Paterson NG, McAuley KE, Lesniak R, Gangar M, Von Delft F, Brem J, Chibale K, Schofield CJ, Dowson CG. J Med Chem. 2021;64(15):11379-94. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00717
Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance. Xiao Y-, Chen X-, Deng J, Yan Y-, Zhu K-, Li G, Yu J-, Brem J, Chen F, Schofield CJ, Li G-. Chem Commun. 2021;57(62):7709-12. Available from: https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc03026d
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis. Rabe P, Kamps JJAG, Sutherlin KD, Linyard JDS, Aller P, Pham CC, Makita H, Clifton I, McDonough MA, Leissing TM, Shutin D, Lang PA, Butryn A, Brem J, Gul S, Fuller FD, Kim I-, Cheah MH, Fransson T, Bhowmick A, Young ID, O'Riordan L, Brewster AS, Pettinati I, Doyle M, Joti Y, Owada S, Tono K, Batyuk A, Hunter MS, Alonso-Mori R, Bergmann U, Owen RL, Sauter NK, Claridge TDW, Robinson CV, Yachandra VK, Yano J, Kern JF, Orville AM, Schofield CJ. Sci Adv. 2021;7(34) Available from: https://www.science.org/doi/10.1126/sciadv.abh0250
Prevalence and risk factors for antimicrobial resistance among newborns with gramnegative sepsis. Solomon S, Akeju O, Odumade OA, Ambachew R, Gebreyohannes Z, Wickle KV, Abayneh M, Metaferia G, Carvalho MJ, Thomson K, Sands K, Walsh TR, Milton R, Goddard FGB, Bekele D, Chan GJ. PLoS ONE. 2021;16(8 August) Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255410
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