Publications

All publications

2022

Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic. Jangir, P.K., Yang, Q., Shaw, L.P., Caballero, J.D., Ogunlana, L., Wheatley, R., Walsh, T.R., MacLean, R.C. eLife. 2022;11:e78834. Available from: https://elifesciences.org/articles/78834

Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Carvalho, M.J., Sands, K., Thomson, K., Portal, E., Mathias, J., Milton, R., Gillespie, D., Dyer, C., Akpulu, C., Boostrom, I., Hogan, P., Saif, H., Ferreira, A., Nieto, M., Hender, T., Hood, K., Andrews, R., Watkins, W. J., Hassan, B., Chan, G., Bekele, D., Solomon, S., Metaferia, G., Basu, S., Naha, S., Sinha, A., Chakravorty, P., Mukherjee, S., Iregbu, K., Modibbo, F., Uwaezuoke, S., Audu, L., Edwin, C.P., Yusuf, A.H., Adeleye, A., Mukkadas, A.S., Zahra, R., Shirazi, H., Muhammad, A., Ullah, S.N., Jan, M.H., Akif, S., Mazarati, J.B., Rucogoza, A., Gaju, L., Mehtar, S., Bulabula, A.N.H., Whitelaw, A., Roberts, L., BARNARDS Group, Walsh, T.R. Nat Microbiol. 2022;7:1337–47. Available from: https://www.nature.com/articles/s41564-022-01184-y

Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries. Sands K, Carvalho MJ, Spiller OB, Portal EAR, Thomson K, Watkins WJ, Mathias J, Dyer C, Akpulu C, Andrews R, Ferreira A, Hender T, Milton R, Nieto M, Zahra R, Shirazi H, Muhammad A, Akif S, Jan MH, Iregbu K, Modibbo F, Uwaezuoke S, Chan GJ, Bekele D, Solomon S, Basu S, Nandy RK, Naha S, Mazarati J-, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, Walsh TR. BMC Infect Dis. 2022;22(1) Available from: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07541-w

Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Chowdhury R, Abboud MI, Wiley J, Tumber A, Markolovic S, Schofield CJ. Sci Rep. 2022;12(1) Available from: https://www.nature.com/articles/s41598-022-10028-y

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins. Belle R, Kamps JJAG, Poater J, Kumar K, Pieters BJGE, Salah E, Claridge TDW, Paton RS, Bickelhaupt FM, Kawamura A, Schofield CJ, Mecinović J. Commun Chem. 2022;5(1) Available from: https://www.nature.com/articles/s42004-022-00640-4

Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation. Brewitz L, Onisko BC, Schofield CJ. J Biol Chem. 2022;298(8) Available from: https://www.jbc.org/article/S0021-9258(22)00570-1/fulltext

Global burden of antimicrobial resistance: Essential pieces of a global puzzle. Walsh TR, Zahra R, Iregbu K, Peacock SJ, Stewardson A. Lancet. 2022;399(10344):2347-8. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00939-4/fulltext

Penicillin derivatives inhibit the SARS-CoV-2 main protease by reaction with its nucleophilic cysteine. Malla TR, Brewitz L, Muntean D-, Aslam H, Owen CD, Salah E, Tumber A, Lukacik P, Strain-Damerell C, Mikolajek H, Walsh MA, Schofield CJ. J Med Chem. 2022;65(11):7682-96. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02214

Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins. Leissing TM, Hardy AP, Chan H, Wang Y, Tumber A, Chowdhury R, Feng T, Coleman ML, Cockman ME, Kramer HB, Berridge G, Fischer R, Kessler BM, Ratcliffe PJ, Lu X, Schofield CJ. J Biol Chem. 2022;298(6) Available from: https://www.jbc.org/article/S0021-9258(22)00460-4/fulltext

Mass spectrometric assays reveal discrepancies in inhibition profiles for the SARS-CoV-2 papain-like protease. Brewitz L, Kamps JJAG, Lukacik P, Strain-Damerell C, Zhao Y, Tumber A, Malla TR, Orville AM, Walsh MA, Schofield CJ. ChemMedChem. 2022;17(9) Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202200016

Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem J, Schofield CJ. Proc Natl Acad Sci U S A. 2022;119(18) Available from: https://www.pnas.org/doi/10.1073/pnas.2117310119

To our friend, John. Walsh TR, Pittet D. Lancet Infect Dis. 2022;22(5):583-4. Available from: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00182-7/fulltext

Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: An international multisite prospective observational study. Milton R, Gillespie D, Dyer C, Taiyari K, Carvalho MJ, Thomson K, Sands K, Portal EAR, Hood K, Ferreira A, Hender T, Kirby N, Mathias J, Nieto M, Watkins WJ, Bekele D, Abayneh M, Solomon S, Basu S, Nandy RK, Saha B, Iregbu K, Modibbo FZ, Uwaezuoke S, Zahra R, Shirazi H, Najeeb SU, Mazarati J-, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw AC, Walsh TR, BARNARDS Group, Chan GJ. Lancet Global Health. 2022;10(5):e661-72. Available from: https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(22)00043-2/fulltext

Silent circulation of BKC-1-producing Klebsiella pneumoniae ST442: Molecular and clinical characterization of an early and unreported outbreak. Martins WMBS, Lenzi MH, Narciso AC, Dantas PP, Andrey DO, Yang QE, Sands K, Medeiros EA, Walsh TR, Gales AC. Int J Antimicrob Agents. 2022;59(5) Available from: https://www.sciencedirect.com/science/article/abs/pii/S0924857922000681

Genomic insights into the mechanism of carbapenem resistance dissemination in Enterobacterales from a tertiary public heath setting in South Asia. Farzana R, Jones LS, Rahman MA, Sands K, van Tonder AJ, Portal E, Criollo JM, Parkhill J, Guest MF, John Watkins W, Pervin M, Boostrom I, Hassan B, Mathias J, Kalam MA, Walsh TR. Clin Infect Dis. 2022:ciac287. Available from: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac287/6567427

Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Kaur S, Tam NY, McDonough MA, Schofield CJ, Aik WS. Nucleic Acids Res. 2022;50(7):4148-60. Available from: https://academic.oup.com/nar/article/50/7/4148/6554164

Expanding the repertoire of low-molecular-weight pentafluorosulfanyl-substituted scaffolds. Jose A, Guest D, LeGay R, Tizzard GJ, Coles SJ, Derveni M, Wright E, Marrison L, Lee AA, Morris A, Robinson M, von Delft F, Fearon D, Koekemoer L, Matviuk T, Aimon A, Schofield CJ, Malla TR, London N, Greenland BW, Bagley MC, Spencer J, The Covid Moonshot Consortium. ChemMedChem. 2022;17(7) Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.202100641

Comparing long-read assemblers to explore the potential of a sustainable low-cost, low-infrastructure approach to sequence antimicrobial resistant bacteria with oxford nanopore sequencing. Boostrom I, Portal EAR, Spiller OB, Walsh TR, Sands K. Front Microbiol. 2022;13 Available from: https://www.frontiersin.org/articles/10.3389/fmicb.2022.796465/full

Distinct increase in antimicrobial resistance genes among Escherichia coli during 50 years of antimicrobial use in livestock production in China. Yang L, Shen Y, Jiang J, Wang X, Shao D, Lam MMC, Holt KE, Shao B, Wu C, Shen J, Walsh TR, Schwarz S, Wang Y, Shen Z. Nat Food. 2022;3(3):197-205. Available from: https://www.nature.com/articles/s43016-022-00470-6

Studies on the reactions of biapenem with VIM metallo β-lactamases and the serine β-lactamase KPC-2. Lucic A, Malla TR, Calvopiña K, Tooke CL, Brem J, McDonough MA, Spencer J, Schofield CJ. Antibiotics. 2022;11(3) Available from: https://www.mdpi.com/2079-6382/11/3/396

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: Implications for its role in viral genome stability and inhibitor identification. Baddock HT, Brolih S, Yosaatmadja Y, Ratnaweera M, Bielinski M, Swift LP, Cruz-Migoni A, Fan H, Keown JR, Walker AP, Morris GM, Grimes JM, Fodor E, Schofield CJ, Gileadi O, McHugh PJ. Nucleic Acids Res. 2022;50(3):1484-500. Available from: https://academic.oup.com/nar/article/50/3/1484/6509090

Structure-activity studies reveal scope for optimisation of ebselen-type inhibition of SARS-CoV-2 main protease. Thun-Hohenstein STD, Suits TF, Malla TR, Tumber A, Brewitz L, Choudhry H, Salah E, Schofield CJ. ChemMedChem. 2022;17(4) Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100582

Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Antimicrobial Resistance Collaborators. Lancet. 2022;399(10325):629-55. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis. Brereton CJ, Yao L, Davies ER, Zhou Y, Vukmirovic M, Bell JA, Wang S, Ridley RA, Dean LSN, Andriotis OG, Conforti F, Brewitz L, Mohammed S, Wallis T, Tavassoli A, Ewing RM, Alzetani A, Marshall BG, Fletcher SV, Thurner PJ, Fabre A, Kaminski N, Richeldi L, Bhaskar A, Schofield CJ, Loxham M, Davies DE, Wang Y, Jones MG. eLife. 2022;11 Available from: https://elifesciences.org/articles/69348

Synthesis and application of constrained amidoboronic acids using amphoteric boron-containing building blocks. Soor HS, Diaz DB, Tsui KY, Calvopiña K, Bielinski M, Tantillo DJ, Schofield CJ, Yudin AK. J Org Chem. 2022;87(1):94-102. Available from: https://pubs.acs.org/doi/10.1021/acs.joc.1c02015

Inhibition of JMJD6 by 2-oxoglutarate mimics. Islam MS, Thinnes CC, Holt-Martyn JP, Chowdhury R, McDonough MA, Schofield CJ. ChemMedChem. 2022;17(1) Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100398

Transmission of carbapenem resistance between human and animal NDM-positive Escherichia coli strains. Shen Y, Hu F, Wang Y, Yin D, Yang L, Chen Y, Xu C, Li J, Jiang J, Wang X, Fu Y, Shao D, Liu D, Ma T, Cai C, Shen Z, Wang S, Li J, Zhang R, Ke Y, Wu C, Shen J, Walsh TR, Wang Y. Engineering. 2022 Available from: https://www.sciencedirect.com/science/article/pii/S2095809922002089

Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease. Liu H, Xie Y, Wang X, Abboud MI, Ma C, Ge W, Schofield CJ. Alzheimer's Dementia. 2022 Available from: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12733

Early-onset neonatal sepsis in low-and middle-income countries: Current challenges and future opportunities. Sands K, Spiller OB, Thomson K, Portal EAR, Iregbu KC, Walsh TR. Infect Drug Resist. 2022;15:933-46. Available from: https://www.dovepress.com/early-onset-neonatal-sepsis-in-low--and-middle-income-countries-curren-peer-reviewed-fulltext-article-IDR

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors. Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt (Adrian) J, Calvopiña K, Turrientes M-, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Nat Chem. 2022;14(1):15-24. Available from: https://www.nature.com/articles/s41557-021-00831-x

2021

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations. Hvinden IC, Cadoux-Hudson T, Schofield CJ, McCullagh JSO. Cell Rep Med. 2021;2(12) Available from: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(21)00341-4

One-step synthesis of photoaffinity probes for live-cell MS-based proteomics. Fallon DJ, Lehmann S, Chung C-, Phillipou A, Eberl C, Fantom KGM, Zappacosta F, Patel VK, Bantscheff M, Schofield CJ, Tomkinson NCO, Bush JT. Chem Eur J. 2021;27(71):17880-8. Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202102036

First-in-class inhibitors of the ribosomal oxygenase MINA53. Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, Simelis K, Kawamura A, Johansson C, Passeri D, Pellicciari R, Ciogli A, Del Bufalo D, Ragno R, Coleman ML, Trisciuoglio D, Mai A, Oppermann U, Schofield CJ, Rotili D. J Med Chem. 2021;64(23):17031-50. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00605

Impact of carbapenem resistance on mortality in patients infected with Enterobacteriaceae: A systematic review and meta-analysis. Zhou R, Fang X, Zhang J, Zheng X, Shangguan S, Chen S, Shen Y, Liu Z, Li J, Zhang R, Shen J, Walsh TR, Wang Y. BMJ Open. 2021;11(12) Available from: https://bmjopen.bmj.com/content/11/12/e054971.long

Isocitrate dehydrogenase gene variants in cancer and their clinical significance. Cadoux-Hudson T, Schofield CJ, McCullagh JSO. Biochem Soc Trans. 2021;49(6):2561-72. Available from: https://portlandpress.com/biochemsoctrans/article/49/6/2561/230356/Isocitrate-dehydrogenase-gene-variants-in-cancer

2-oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nakashima Y, Brewitz L, Tumber A, Salah E, Schofield CJ. Nat Commun. 2021;12(1) Available from: https://www.nature.com/articles/s41467-021-26673-2

Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1. Liu S, Abboud MI, John T, Mikhailov V, Hvinden I, Walsby-Tickle J, Liu X, Pettinati I, Cadoux-Hudson T, McCullagh JSO, Schofield CJ. Commun Biolog. 2021;4(1) Available from: https://www.nature.com/articles/s42003-021-02743-5

Expansion of KPC-producing Enterobacterales in four large hospitals in Hanoi, Vietnam. Linh TD, Thu NH, Shibayama K, Suzuki M, Yoshida L, Thai PD, Anh DD, Duong TN, Trinh HS, Thom VP, Nga LTV, Phuong NTK, Thuyet BT, Walsh TR, Thanh LV, Bañuls A-, van Doorn HR, Van Anh T, Hoang TH. J Global Antimicrob Resist. 2021;27:200-11. Available from: https://www.sciencedirect.com/science/article/pii/S2213716521002137?via%3Dihub

Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: An international microbiology and drug evaluation prospective substudy (BARNARDS). Thomson KM, Dyer C, Liu F, Sands K, Portal E, Carvalho MJ, Barrell M, Boostrom I, Dunachie S, Farzana R, Ferreira A, Frayne F, Hassan B, Jones E, Jones L, Mathias J, Milton R, Rees J, Chan GJ, Bekele D, Mahlet A, Basu S, Nandy RK, Saha B, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Syed NU, Mazarati J-, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, van Hasselt JGC, Walsh TR, on behalf of the BARNARDS Group. Lancet Infect Dis. 2021;21(12):1677-88. Available from: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2821%2900050-5/fulltext

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Butryn A, Simon PS, Aller P, Hinchliffe P, Massad RN, Leen G, Tooke CL, Bogacz I, Kim I-, Bhowmick A, Brewster AS, Devenish NE, Brem J, Kamps JJAG, Lang PA, Rabe P, Axford D, Beale JH, Davy B, Ebrahim A, Orlans J, Storm SLS, Zhou T, Owada S, Tanaka R, Tono K, Evans G, Owen RL, Houle FA, Sauter NK, Schofield CJ, Spencer J, Yachandra VK, Yano J, Kern JF, Orville AM. Nat Commun. 2021;12(1) Available from: https://www.nature.com/articles/s41467-021-24757-7

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Redhead MA, Owen CD, Brewitz L, Collette AH, Lukacik P, Strain-Damerell C, Robinson SW, Collins PM, Schäfer P, Swindells M, Radoux CJ, Hopkins IN, Fearon D, Douangamath A, von Delft F, Malla TR, Vangeel L, Vercruysse T, Thibaut J, Leyssen P, Nguyen T-, Hull M, Tumber A, Hallett DJ, Schofield CJ, Stuart DI, Hopkins AL, Walsh MA. Sci Rep. 2021;11(1) Available from: https://www.nature.com/articles/s41598-021-92416-4

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Davydova E, Shimazu T, Schuhmacher MK, Jakobsson ME, Willemen HLDM, Liu T, Moen A, Ho AYY, Małecki J, Schroer L, Pinto R, Suzuki T, Grønsberg IA, Sohtome Y, Akakabe M, Weirich S, Kikuchi M, Olsen JV, Dohmae N, Umehara T, Sodeoka M, Siino V, McDonough MA, Eijkelkamp N, Schofield CJ, Jeltsch A, Shinkai Y, Falnes PØ. Nat Commun. 2021;12(1) Available from: https://www.nature.com/articles/s41467-020-20670-7

Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. Powell LC, Abdulkarim M, Stokniene J, Yang QE, Walsh TR, Hill KE, Gumbleton M, Thomas DW. npj Biofilms and Microbiomes. 2021;7(1) Available from: https://www.nature.com/articles/s41522-020-00172-6

Structure-based design of selective fat mass and obesity associated protein (FTO) inhibitors. Shishodia S, Demetriades M, Zhang D, Tam NY, Maheswaran P, Clunie-O'Connor C, Tumber A, Leung IKH, Ng YM, Leissing TM, El-Sagheer AH, Salah E, Brown T, Aik WS, McDonough MA, Schofield CJ. J Med Chem. 2021;64(22):16609-25. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01204

Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding. Chan HTH, Moesser MA, Walters RK, Malla TR, Twidale RM, John T, Deeks HM, Johnston-Wood T, Mikhailov V, Sessions RB, Dawson W, Salah E, Lukacik P, Strain-Damerell C, Owen CD, Nakajima T, Świderek K, Lodola A, Moliner V, Glowacki DR, Spencer J, Walsh MA, Schofield CJ, Genovese L, Shoemark DK, Mulholland AJ, Duarte F, Morris GM. Chem Sci. 2021;12(41):13686-703. Available from: https://pubs.rsc.org/en/content/articlelanding/2021/sc/d1sc03628a

A new mutation in mgrb mediating polymyxin resistance in klebsiella variicola. Lenzi MH, Martins WM, Roch M, Ramos PL, Sands K, Cayô R, Walsh TR, Andrey DO, Gales AC. Int J Antimicrob Agents. 2021;58(5) Available from: https://pubmed.ncbi.nlm.nih.gov/34419577/

A role for arthropods as vectors of multidrug-resistant Enterobacterales in surgical site infections from South Asia. Hassan B, Ijaz M, Khan A, Sands K, Serfas G-, Clayfield L, El-Bouseary MM, Lai G, Portal E, Khan A, Watkins WJ, Parkhill J, Walsh TR. Nat Microbiol. 2021;6(10):1259-70. Available from: https://www.nature.com/articles/s41564-021-00965-1

Kinetic and structural characterization of the first B3 metallob-lactamase with an active-site glutamic acid. Wilson LA, Knaven EG, Morris MT, Pedroso MM, Schofield CJ, Brück TB, Boden M, Waite DW, Hugenholtz P, Guddat L, Schenk G. Antimicrob Agents Chemother. 2021;65(10) Available from: https://journals.asm.org/doi/10.1128/AAC.00936-21

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. Baddock HT, Newman JA, Yosaatmadja Y, Bielinski M, Schofield CJ, Gileadi O, McHugh PJ. Nucleic Acids Res. 2021;49(16):9294-309. Available from: https://academic.oup.com/nar/article/49/16/9294/6350770

Structural and mechanistic insights into the artemis endonuclease and strategies for its inhibition. Yosaatmadja Y, Baddock HT, Newman JA, Bielinski M, Gavard AE, Mukhopadhyay SMM, Dannerfjord AA, Schofield CJ, McHugh PJ, Gileadi O. Nucleic Acids Res. 2021;49(16):9310-26. Available from: https://academic.oup.com/nar/article/49/16/9310/6350767

Emergence of plasmid-mediated tigecycline resistance tet(X4) gene in Escherichia coli isolated from poultry, food and the environment in South Asia. Mohsin M, Hassan B, Martins WMBS, Li R, Abdullah S, Sands K, Walsh TR. Sci Total Environ. 2021;787 Available from: https://www.sciencedirect.com/science/article/abs/pii/S004896972102684X

Mobile colistin resistance enzyme MCR-3 facilitates bacterial evasion of host phagocytosis. Yin W, Ling Z, Dong Y, Qiao L, Shen Y, Liu Z, Wu Y, Li W, Zhang R, Walsh TR, Dai C, Li J, Yang H, Liu D, Wang Y, Gao GF, Shen J. Adv Sci. 2021;8(18) Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202101336

What is the catalytic mechanism of enzymatic histone N-methyl arginine demethylation and can it be influenced by an external electric field? Ramanan R, Waheed SO, Schofield CJ, Christov CZ. Chem Eur J. 2021;27(46):11750. Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202101174

What is the catalytic mechanism of enzymatic histone N-methyl arginine demethylation and can it be influenced by an external electric field? Ramanan R, Waheed SO, Schofield CJ, Christov CZ. Chem Eur J. 2021;27(46):11827-36. Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202101174

High-throughput crystallography reveals boron-containing inhibitors of a penicillin-binding protein with di- and tricovalent binding modes. Newman H, Krajnc A, Bellini D, Eyermann CJ, Boyle GA, Paterson NG, McAuley KE, Lesniak R, Gangar M, Von Delft F, Brem J, Chibale K, Schofield CJ, Dowson CG. J Med Chem. 2021;64(15):11379-94. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00717

Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance. Xiao Y-, Chen X-, Deng J, Yan Y-, Zhu K-, Li G, Yu J-, Brem J, Chen F, Schofield CJ, Li G-. Chem Commun. 2021;57(62):7709-12. Available from: https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc03026d

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis. Rabe P, Kamps JJAG, Sutherlin KD, Linyard JDS, Aller P, Pham CC, Makita H, Clifton I, McDonough MA, Leissing TM, Shutin D, Lang PA, Butryn A, Brem J, Gul S, Fuller FD, Kim I-, Cheah MH, Fransson T, Bhowmick A, Young ID, O'Riordan L, Brewster AS, Pettinati I, Doyle M, Joti Y, Owada S, Tono K, Batyuk A, Hunter MS, Alonso-Mori R, Bergmann U, Owen RL, Sauter NK, Claridge TDW, Robinson CV, Yachandra VK, Yano J, Kern JF, Orville AM, Schofield CJ. Sci Adv. 2021;7(34) Available from: https://www.science.org/doi/10.1126/sciadv.abh0250

Prevalence and risk factors for antimicrobial resistance among newborns with gramnegative sepsis. Solomon S, Akeju O, Odumade OA, Ambachew R, Gebreyohannes Z, Wickle KV, Abayneh M, Metaferia G, Carvalho MJ, Thomson K, Sands K, Walsh TR, Milton R, Goddard FGB, Bekele D, Chan GJ. PLoS ONE. 2021;16(8 August) Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255410

Structural basis of prolyl hydroxylase domain inhibition by molidustat. Figg WD, McDonough MA, Chowdhury R, Nakashima Y, Zhang Z, Holt-Martyn JP, Krajnc A, Schofield CJ. ChemMedChem. 2021;16(13):2082-8. Available from: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100133

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. Brewitz L, Nakashima Y, Tumber A, Salah E, Schofield CJ. J Fluor Chem. 2021;247 Available from: https://www.sciencedirect.com/science/article/pii/S0022113921000828

Human oxygenase variants employing a single protein FeII ligand are catalytically active. Brasnett A, Pfeffer I, Brewitz L, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield CJ. Angew Chem Int Ed. 2021;60(26):14657-63. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202103711

Structural basis of metallo-β-lactamase inhibition by N-sulfamoylpyrrole-2-carboxylates. Farley AJM, Ermolovich Y, Calvopiña K, Rabe P, Panduwawala T, Brem J, Björkling F, Schofield CJ. ACS Infect Dis. 2021;7(6):1809-17. Available from: https://pubs.acs.org/doi/10.1021/acsinfecdis.1c00104

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: A potential hypoxia response modulating strategy. Wu Y, Li Z, McDonough MA, Schofield CJ, Zhang X. J Med Chem. 2021;64(11):7189-209. Available from: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00415

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2. Richardson NL, O'Malley LJ, Weissberger D, Tumber A, Schofield CJ, Griffith R, Jones NM, Hunter L. Bioorg Med Chem. 2021;38 Available from: https://www.sciencedirect.com/science/article/abs/pii/S0968089621001231

Faropenem reacts with serine and metallo-β-lactamases to give multiple products. Lucic A, Hinchliffe P, Malla TR, Tooke CL, Brem J, Calvopiña K, Lohans CT, Rabe P, McDonough MA, Armistead T, Orville AM, Spencer J, Schofield CJ. Eur J Med Chem. 2021;215 Available from: https://www.sciencedirect.com/science/article/abs/pii/S0223523421001069

Characterization of antimicrobial-resistant gram-negative bacteria that cause neonatal sepsis in seven low- and middle-income countries. Sands K, Carvalho MJ, Portal E, Thomson K, Dyer C, Akpulu C, Andrews R, Ferreira A, Gillespie D, Hender T, Hood K, Mathias J, Milton R, Nieto M, Taiyari K, Chan GJ, Bekele D, Solomon S, Basu S, Chattopadhyay P, Mukherjee S, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Muhammad A, Mazarati J-, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, Walsh TR. Nat Microbiol. 2021;6(4):512-23. Available from: https://www.nature.com/articles/s41564-021-00870-7