The IOI hosts a multidisciplinary research programme that is based on a wide range of capabilities that include AMR surveillance, the characterisation of mechanisms of drug resistance and modes of action of antibiotics, and drug discovery and development.

AMR burden and surveillance

  • International studies with global surveillance and assessment programmes in LMICs
  • Bacterial culturing
  • Global AMR strain collection
  • Molecular epidemiology
  • Antibiotic susceptibility profiling
  • Next-generation sequencing

Molecular mechanisms

  • Characterization of mechanisms of drug action
  • Elucidation of resistance mechanisms
  • Next-generation sequencing
  • Bacterial culturing
  • Antibiotic susceptibility profiling
  • Molecular microbiology
  • Protein/target production¬†
  • Protein analysis
  • Structural biology

Drug discovery

  • High-throughput screening
  • Biochemical and cell-based assays
  • PK/PD and ADME evaluations
  • Assay development
  • Compound libraries
  • Small molecule analysis
  • Target validation
  • Structural elucidation

Drug development

  • Medicinal/synthetical chemistry
  • Biosynthesis
  • Compound optimization
  • Drug metabolism & pharmacokinetics
  • Structural biology
  • In vivo testing

In-silico analyses

  • Bioinformatics
  • Computational chemistry
  • Structural modelling